Downloads

Below is a list of downloads available from Catalysis Consulting.

Introduction to Design of Experiments (DoE)

Introduction to Principal Component Analysis (PCA)

Combining Design of Experiments and Principal Component Analysis

Case Study 1: Identifying an alternative catalyst systems for a Suzuki reaction reducing the catalyst cost of the process by more than $400,000.

Case Study 2: Identifying an alternative catalyst systems for a Buchwald Hartwig amination reaction reducing the catalyst cost of the process by more than $280,000.

Case Study 3: Rapid identification of an alternative catalyst system for a low yielding Suzuki reaction to support the delivery of 5 kg of an API intermediate through understanding.

Case Study 4: Identifying an alternative catalyst and solvent system for a Suzuki reaction reducing the catalyst cost of the process by more than £140,000 while providing a more robust process which reliably double the isolated yield.

Case Study 5: The elimination of a new impurity observed during the scale-up of a catalytic reaction was enabled based on mechanistic understanding of catalytic reactions.

Representative Biotransformations